Numerous diseases can be exacerbated by excessive blood fat levels. The effects of obesity, high cholesterol, and triglyceride levels are harmful to the body. Recent studies suggest that higher blood fat concentrations may have even more detrimental effects on health than previously believed.
Muscle cells become weighed down by fat, which harms both their structure and function. Recent studies have demonstrated that under stress, cells release a signal that can spread to other cells and increase cellular damage.
Ceramide molecules, whose main purpose is to lessen cellular stress, are used as the signals. Yet, they can cause cell death and aggravate disease symptoms in long-term metabolic conditions like type II diabetes.
Our study may serve as the foundation for future treatments or therapeutic strategies to avoid the onset of cardiovascular and metabolic disorders like diabetes in persons with raised blood fat levels in obesity, even if the research is still in its early phases.
Newly identified ceramide migration
The addition of a fatty acid known as palmitate allowed the researchers to activate ceramide signaling in human skeletal muscle cells created to resemble those of persons with metabolic disorders.
These cells carried ceramides in bundles known as extracellular vesicles, which are naturally released by all cells, and started to communicate with each other when they were mixed with cells that had not been exposed to lipids.
Researchers observed the same processes in tests conducted on mice and muscle cells taken from humans (volunteers).
Ceramides are known to be harmful to the body, but the researchers say that more research is needed to figure out what the movement of ceramides found recently means.
According to the researchers, even more unknown factors may be at play. The messaging system is potentially one way that people with obesity develop further complications, such as diabetes.
The latest discoveries regarding the new transmission system may prove helpful in preventing the development of possible complications by blocking ceramides. More research is needed to determine further treatments.