BOSTON: We know that the most common cause of untreatable deafness is the loss of hair cells in the inner ear that detect sound vibrations. Their regeneration has now seen significant success thanks to the combination of different drugs.
The hair cells inside the ear, whether human or mammalian, act as sensitive sensors and do not regenerate once destroyed. Professor Zeng Y. Chen of Mass. Brigham General Hospital in Massachusetts and his colleagues have now developed not only a combination of different molecules to regrow damaged hair cells in the ear of mice, but also the genetic pathway underlying this process. Way) has been reprogrammed as well.
The findings were published in the Proceedings of the National Academy of Sciences, and it is hoped that gene therapy will one day be able to restore hearing, which has long been a source of consternation in medical science. Millions of people around the world, including Pakistan, are deafened due to this condition, and this treatment is a ray of hope for them.
The researchers also looked at cell division in zebrafish and chickens to see how new hearing cells are formed. At the molecular level, they observed signal release and its pathways. Then, in 2019, when mice were studied, it was discovered that genetic modification caused hearing cells to form in their ears. Several molecules have also been used to activate ATOH1, and they have been mixed with a harmless adenovirus to create hearing cells, according to the experts. However, the benefits to humans are still far off.